Characterization of natural product inhibitors of quorum sensing in Pseudomonas aeruginosa reveals competitive inhibition of RhlR by ortho-vanillin
K. E. Woods, S. Akhter, B. L. Rodriguez, K. A. Townsend, N. C. Smith, A. N. Wambua, V. Craddock, E. E. Santa, D. E. Manson, R. G. Abisado-Duque, B. R. Oakley, L. E. Hancock, Y. Miao, H. E. Blackwell, J. R. Chandler
This study evaluates benzaldehyde derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa, identifying ortho-vanillin as a competitive inhibitor of RhlR.
bioRxiv · Feb 24, 2024 · PreprintMicrobiology