J. R. Chandler

This study investigates how Chromobacterium subtsugae regulates antibiotic resistance genes through quorum sensing and a TetR-family repressor, showing independent modulation by CviR and CdeR.

This study shows that a mutation in fusA1 enhances tobramycin resistance in lasR-null Pseudomonas aeruginosa mutants through interactions with the MexXY efflux pump and ArmZ regulator.

This study shows that promiscuous quorum-sensing receptors in Chromobacterium subtsugae allow cross-species activation of hydrogen cyanide production, giving it a competitive advantage in a dual-species model.

This study shows tobramycin suppresses lasR mutants in Pseudomonas aeruginosa by directly targeting cheaters and selecting for mutations that enhance pyocyanin-mediated policing.

This study identifies N-oxidated methyl-alkenylquinolines (HMAQ-NOs) as antimicrobial compounds produced by Burkholderia thailandensis, showing they are 50-fold more active than their non-oxidized counterparts against Bacillus subtilis.

This paper identifies two RND-family efflux pumps in Chromobacterium species that confer antibiotic resistance and enhance competitive survival in co-culture with Burkholderia thailandensis.

This study shows that the C. elegans protein PBO-1 regulates intestinal pH, which is critical for pathogen defense through reactive oxygen species production.