New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescence
S. N. Parkar, A. C. Ramalho, M. J. Lopez-Iniesta, R. Silva, J. Zhao, K. Kimura, V. Dassi, F. da Silva Rita, Y. Ciribilli, A. Bisio, L. Romao, M. M. Candeias
The paper identifies a new p53 isoform, Δ246p53, which is induced by DNA damage, promotes senescence, and modulates p21 expression through interactions with FLp53 and ΔNp63.
bioRxiv · Apr 7, 2023Cancer Biology