Cancer BiologybioRxiv
New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescence
S. N. Parkar, A. C. Ramalho, M. J. Lopez-Iniesta…·M. M. Candeias
The paper identifies a new p53 isoform, Δ246p53, which is induced by DNA damage, promotes senescence, and modulates p21 expression through interactions with FLp53 and ΔNp63.
DOI 10.1038/s41420-026-03374-7