Cancer BiologybioRxiv
Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML
B. Q. Trinh, S. Ummarino, A. K. Ebralidze…·D. G. Tenen
The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.
DOI 10.1182/blood.2020007920