Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism
V. Fernando, X. Zheng, V. Sharma, S. Furuta
This study shows that sepiapterin reprograms M2-type tumor-associated macrophages in HER2+ breast tumors to M1-type by modulating arginine metabolism, enhancing immunotherapy response.
bioRxiv · Aug 22, 2023Cancer Biology