X. Zheng

The paper identifies slow-growing, avirulent malaria parasite mutants that protect against disease after challenge with wild-type parasites.

This study shows that senescent primary oocytes contribute to ovarian aging in mice, and their removal improves fertility and follicle numbers.

This study shows that microbial communities with metabolic redundancy outperform both specialized and division-of-labor systems in naphthalene degradation.

This study investigates how iron limitation increases BMAA-containing protein production in marine diatoms and identifies cysK as a key enzyme in BMAA biosynthesis.

This study uses multi-omic analyses to identify molecular features and biomarkers in early and advanced hepatocellular carcinoma stages.

This study compares scholarly outputs from intramural and extramural NIH grants, finding extramural grants are more cost-effective for publications and citations, while intramural grants are better for clinical impact.

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

This study shows that overexpressing Zaxinone Synthase in rice increases zaxinone levels, enhances growth, and improves phosphate uptake, leading to higher grain yield.

This study identifies ULK1-mediated phosphorylation of PKM2 that inhibits O-GlcNAcylation and reduces the Warburg effect in breast cancer.

This study shows that sepiapterin reprograms M2-type tumor-associated macrophages in HER2+ breast tumors to M1-type by modulating arginine metabolism, enhancing immunotherapy response.

The paper uses associative transcriptomics to identify host genetic loci associated with quantitative disease resistance in oilseed rape to four fungal pathogens, finding that resistance depends on pathogen lifestyle rather than broad-spectrum resistance.

This study identifies T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort using mass cytometry and random forest analysis.

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

This paper analyzes the ecological diversity and evolution of Enantiornithes by introducing new data on Bohaiornithidae and integrating it with existing data on other enantiornithine families.

This paper demonstrates that co-targeting essential and DNA repair genes enhances CRISPR-Cas antifungal efficacy in yeast, outperforming single-target approaches.

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

This study identifies SIX4 as a regulator of STING expression in colon cancer, showing it enhances anti-PD-1 therapy efficacy by promoting STING activation and CD8+ T-cell infiltration.

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.

This study identifies how bacterial contact triggers polar plug disintegration in whipworm eggs, facilitating larval hatching through chitinase activity rather than bacterial enzymes.

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

This study examines how publishing COVID-19 papers affected journal citation metrics, finding early entrants gained citation premiums that declined over time.

The paper investigates how repeated heat stress affects gene regulation in Brachypodium distachyon, identifying long noncoding RNA and miRNA roles in stress memory and resilience.

This study identifies Esm-1 as a marker and mediator of transcriptional polarization in diabetic kidney disease using single-cell and bulk transcriptomic data.

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

This paper develops a 3D adrenocortical carcinoma tumor platform to study drug response and MMP activity, showing decreased drug sensitivity and active MMP-mediated invasion in 3D.

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

The paper identifies LePin as a key lectin in coral-algal recognition and uses RNAi and scRNA-seq to uncover gene programs and receptors involved in algal uptake and symbiosome formation.