Streptococcal meningoencephalitis dynamically shapes developmental monocyte and macrophage trajectories in the CNS
V. Gres, F. Lohrmann, V. Fuchs, J. Neuber, Z. Mansoori Moghadam, A. K. Lösslein, L. F. Pahutan Bosch, T. Figueiral-Martins, S. Baasch, D. Obwegs, G. Monaco, J. Henschel, K. P. Knobeloch, M. Prinz, S. Jung, , P. Henneke
This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.
bioRxiv · Feb 27, 2024 · PreprintImmunology