ADP-ribosylation of mitochondrial proteins is mediated by Neuralized-like protein 4 (NEURL4)
M. D. Cardamone, Y. Gao, J. Kwan, V. Hayashi, M. Sheeran, J. Xu, J. English, J. Orofino, A. Emili, V. Perissi
This study identifies NEURL4 as the main mitochondrial ADP-ribosyltransferase and shows it regulates mtDNA integrity through poly-ADP-ribosylation of mtLIG3.
bioRxiv · Dec 28, 2020Cell Biology