A. Emili

Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays

The paper develops a method to discover RNA-protein-small molecule complexes using proteome-wide stability assays and applies it to identify novel DDX helicase targets of rocaglates.

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

The paper uses proximity labeling to study the dynamic SQSTM1 protein network and shows that aggregated tau alters its interactions with stress-associated proteins.

Development of BODIPY-based fluorescent probes for highly selective amino acid identification

This paper develops BODIPY-based fluorescent probes for selective amino acid identification through optimized spectral and photophysical properties.

High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions

This study identifies additional host proteins involved in SARS-CoV-2 entry using a novel photocatalytic mapping platform called ViraMap.

Zhx2 is a candidate gene underlying oxymorphone metabolite brain concentration associated with state-dependent oxycodone reward

This study identifies Zhx2 as a candidate gene influencing oxymorphone brain concentrations and state-dependent oxycodone reward in female mice.

ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii reveals novel virulence factors implicated in host cell invasion

ToxoNet constructs a high-confidence protein-protein interaction map for Toxoplasma gondii, identifying novel virulence factors involved in host cell invasion.

Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice

This paper uses proteomics to analyze platelet changes in SARS-CoV-2-infected humanized mice, finding early activation of coagulation and complement pathways.

DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling

The paper engineers a DNAJB1-PRKACA fusion in HEK293T cells to study its oncogenic effects, finding LINC00473 overexpression dependent on PKA signaling.

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

This study uses recombinant Lloviu virus to investigate replication mechanisms and host interactions of an uncultured filovirus related to Ebola.

Inhibition of Mul1-mediated ubiquitination promotes mitochondria-associated translation

The paper identifies GPS2 as an inhibitor of Mul1-mediated ubiquitination that regulates mitochondria-associated translation by targeting RNA-binding and translation factors.

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

ADP-ribosylation of mitochondrial proteins is mediated by Neuralized-like protein 4 (NEURL4)

This study identifies NEURL4 as the main mitochondrial ADP-ribosyltransferase and shows it regulates mtDNA integrity through poly-ADP-ribosylation of mtLIG3.

Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

This study uses patient-derived iPSCs with an SFTPC mutation to model early alveolar epithelial dysfunction in interstitial lung disease, revealing proteostasis, metabolic, and inflammatory changes.

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.

SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors

This study identifies multiple innate immune receptors that recognize SARS-CoV-2 spike protein through glycan-dependent interactions, suggesting potential therapeutic targets.

Global Landscape of Native Protein Complexes in Synechocystis sp. PCC 6803

The paper identifies 291 protein complexes and 24,092 PPIs in Synechocystis sp. PCC 6803, revealing functional roles of previously uncharacterized proteins and their interactions across biological processes.

Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo

Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkers

This paper demonstrates that pancreatic tumor organoids (PDOs) recapitulate PDX models' features and can identify clinically-actionable biomarkers in blood.