Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis
V. Kheirollahi, R. M. Wasnick, V. Biasin, A. I. Vazquez-Armendariz, X. Chu, A. Moiseenko, A. Weiss, J. Wilhelm, J.-S. Zhang, G. Kwapiszewska, S. Herold, R. T. Schermuly, W. Seeger, A. Guenther, S. Bellusci, E. El Agha
This study shows metformin reduces lung fibrosis by inducing lipogenic differentiation in myofibroblasts through BMP2-PPARγ signaling and AMPK-dependent collagen reduction.
bioRxiv · Sep 26, 2018Cell Biology