X. Chu

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

Unraveling the Interplay between Stability and Flexibility in Design of Polyethylene Terephthalate (PET) Hydrolases

This study investigates how stability and flexibility balance in PET hydrolases affects catalytic activity, finding that a thermophilic variant shows enhanced performance through structural flexibility.

A neutral process of genome reduction in marine bacterioplankton

The paper investigates genome reduction in marine bacterioplankton, finding that neutral processes like genetic drift, not streamlining selection, drive genome size reduction in the Roseobacter group.

Balancing stability, dynamics and kinetics in phase separation of intrinsically disordered proteins

This study investigates the thermodynamics and kinetics of phase separation in intrinsically disordered proteins using a coarse-grained model, revealing a non-monotonic relationship between interaction strength and condensate formation rates.

Elucidating the activation mechanism for GBP1 oligomerization

This study reveals the activation mechanism of GBP1 oligomerization through cryo-EM structures, showing nucleotide-dependent conformational changes drive dimerization, oligomerization, and membrane binding for pathogen encapsulation.

Quantifying the large-scale chromosome structural dynamics during the mitosis-to-G1 phase transition of cell cycle

This study quantifies chromosome structural dynamics during the mitosis-to-G1 phase transition using a data-driven model and nonequilibrium landscape-switching model, revealing asynchronous structural changes and TAD dynamics.

Biodecomposing Spirulina platensis by a de novo designed Bacillus subtilis-based method to develop a medium for the high cell-density cultivation of Escherichia coli in batch mode

This paper develops a method to biodecompose Spirulina platensis using Bacillus subtilis to create a medium for high cell-density cultivation of Escherichia coli, achieving higher growth rates and optical density than traditional LB broth.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.

A unique cell division protein critical for the assembly of the bacterial divisome

This study identifies Aeg1 as a new essential cell division protein in Acinetobacter baumannii that recruits FtsN to initiate cell division.

Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

Annealing synchronizes the 70S ribosome into a minimum-energy conformation

This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.

Structures of the human cholecystokinin receptors in complex with agonists and antagonists

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

Insights into the molecular mechanisms of cell fate decision making processes from chromosome structural dynamics

This study uses molecular dynamics simulations to analyze chromosome structural dynamics during cell fate transitions, revealing merging pathways and distinct cancer progression routes.

Deciphering the molecular mechanism of the cancer formation by chromosome structural dynamics

The paper uses a landscape-switching model to study chromosomal structural changes during cancerization and reversion, finding non-monotonic structural transitions and structural similarities to embryonic stem cells.

Mechanisms Driving Genome Reduction of a Novel Roseobacter Lineage Showing Vitamin B12 Auxotrophy

The paper identifies a novel Roseobacter lineage, CHUG, with reduced genomes and vitamin B12 auxotrophy, suggesting a free-living lifestyle and genome reduction driven by relaxed purifying selection.

Microscopic Chromosomal Structural and Dynamical Origin of Cell Differentiation and Reprogramming

This study develops a landscape-switching model to explore the chromosomal structural origins of cell differentiation and reprogramming, showing compartment-switching and compaction patterns during differentiation and over-expansion during reprogramming.

Micro-XRF study of the troodontid dinosaur Jianianhualong tengi reveals new biological and taphonomical signals

This study uses micro-XRF to analyze the holotype of Jianianhualong tengi, revealing elemental patterns linked to fossil structure and taphonomy.

Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.

Conformational state switching and pathways of chromosome dynamics in cell cycle

This study develops a non-equilibrium model to analyze chromosome conformational changes during the cell cycle, revealing two-stage transitions and irreversible pathways.

Novel pelagiphages prevail in the ocean

This study isolates and characterizes ten novel pelagiphages infecting Pelagibacter strains, revealing their genetic diversity, global distribution, and ecological significance.

Investigations of the Underlying Mechanisms of HIF-1α and CITED2 Binding to TAZ1

This study investigates the competition mechanisms between HIF-1 and CITED2 binding to TAZ1 using structure-based models and simulations.

Low rate of follow-up colonoscopy after positive results of colorectal cancer screening in a Chinese urban core district

The paper assesses CRC screening and follow-up colonoscopy rates in a Chinese urban district, finding low participation and follow-up rates despite high CRC prevalence.

Diverse, abundant and novel viruses infecting \"unculturable\" but abundant marine bacteria

The paper isolates and characterizes seven phages infecting Roseobacter RCA lineage bacteria, revealing genomic diversity and abundance in marine virosphere.

Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

This study uses multi-omics analysis to examine the effects of simulated weightlessness on rhesus macaques, identifying molecular changes in blood, muscle, brain regions, and fecal samples.

Selection for synchronized replication of genes encoding the same protein complex during tumorigenesis

The paper shows that genes encoding the same protein complex replicate synchronously in fast-proliferating cells like cancer cells to maintain stoichiometry, but not in slow-proliferating cells.

Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis

This study shows metformin reduces lung fibrosis by inducing lipogenic differentiation in myofibroblasts through BMP2-PPARγ signaling and AMPK-dependent collagen reduction.