GFAT2 and AMDHD2 act in tandem to control the hexosamine biosynthetic pathway
V. Kroef, S. Ruegenberg, M. Horn, K. Allmeroth, L. Eberg, S. Bozkus, S. Miethe, B. Schermer, U. Baumann, M. S. Denzel
This study identifies AMDHD2 as a new regulator of the hexosamine biosynthetic pathway, showing it balances GFAT2 activity to control UDP-GlcNAc levels in mouse embryonic stem cells.
bioRxiv · Apr 23, 2021Biochemistry