U. Baumann

A family of bacterial Josephin-like deubiquitinases with an unusual cleavage mode

The paper identifies a new family of bacterial deubiquitinases that cleave ubiquitin before the C-terminal diGly motif, truncating the modifier and leaving a remnant on the substrate.

Impaired transitioning of the FXR ligand binding domain to an active state underlies an FXR-associated PFIC phenotype

This study identifies a missense variant in FXR that impairs its conformational transition to an active state, leading to reduced BSEP expression and a PFIC phenotype.

The structural basis for deubiquitination by the fingerless USP-type effector TssM

This study determines the crystal structures of TssM, a USP-type deubiquitinase from B. pseudomallei and B. mallei, revealing its unique structural features and mechanism of ubiquitin recognition.

Structural polymorphisms within a common powdery mildew effector scaffold as a driver of co-evolution with cereal immune receptors

This study reports the structures of powdery mildew effector proteins and shows how structural polymorphisms within a common scaffold drive co-evolution with cereal immune receptors.

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

GFAT2 and AMDHD2 act in tandem to control the hexosamine biosynthetic pathway

This study identifies AMDHD2 as a new regulator of the hexosamine biosynthetic pathway, showing it balances GFAT2 activity to control UDP-GlcNAc levels in mouse embryonic stem cells.

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

This study identifies how PKA phosphorylation of GFAT-1 modulates the hexosamine pathway by altering feedback inhibition and enzyme activity.

AtCIPK16 Mediates Salt Stress Through Phytohormones and Transcription Factors

This study identifies AtCIPK16's role in enhancing salt tolerance in Arabidopsis by regulating phytohormones, transcription factors, and homeostasis.