Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
F. De Leo, G. Quilici, M. Tirone, V. Mannella, F. De Marchis, A. Preti, A. Gori, M. Casalgrandi, R. Mezzapelle, M. Bianchi, G. Musco
This study shows Diflunisal inhibits HMGB1-mediated immune cell recruitment by disrupting the HMGB1/CXCL12 heterocomplex without affecting TLR4-dependent responses.
bioRxiv · Mar 1, 2019Biochemistry