BiochemistrybioRxiv
Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
F. De Leo, G. Quilici, M. Tirone…·G. Musco
This study shows Diflunisal inhibits HMGB1-mediated immune cell recruitment by disrupting the HMGB1/CXCL12 heterocomplex without affecting TLR4-dependent responses.
DOI 10.15252/embr.201947788