M. Bianchi

Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring

This study shows that chronic IFNα treatment in rats causes hypermetabolic immune cells, increased plasma succinate, and impaired bacterial response.

Duplication of NRAMP3 gene in poplars generated two homologous transporters with distinct functions

This paper identifies two NRAMP3 paralogues in poplars with distinct functions: one retains vacuole metal release function, while the other localizes to the TGN and controls manganese cell-to-cell transport.

Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety

This study shows chronic oxytocin increases soluble CRFR2, linked to anxiety, while acute oxytocin reduces anxiety via membrane-bound CRFR2.

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

This study maps polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines and identifies epitopes associated with neutralization breadth.

Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment

This study shows Diflunisal inhibits HMGB1-mediated immune cell recruitment by disrupting the HMGB1/CXCL12 heterocomplex without affecting TLR4-dependent responses.

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

Quantitative Assessment of Colorectal Cancer Progression: a Comparative Study of Linear and Nonlinear Microscopy Techniques

The paper compares linear and nonlinear microscopy techniques to assess colorectal cancer progression in mice, finding that combined signals improve early detection.