A. Gori

Addressing heterogeneity in direct analysis of Extracellular Vesicles and analogues using Membrane-Sensing Peptides as Pan-Affinity Probes

This paper introduces Membrane-Sensing Peptides (MSP) as universal affinity ligands for analyzing Extracellular Vesicles and analogues, demonstrating their ability to detect EV-associated epitopes in clinical samples without prior isolation.

Is HDL-c plasma concentration a possible marker of HIV replication? A cross-sectional analysis in untreated HIV-infected individuals accessing HIV care in Italy

This study examines the relationship between HDL-c levels and HIV viral load in untreated HIV patients, finding a negative correlation but not a strong surrogate marker.

Design and optimization of silicon-based electrokinetic microchip for sensitive detection of small extracellular vesicles

This paper designs and optimizes a silicon-based electrokinetic microchip for sensitive detection of small extracellular vesicles, achieving a low limit of detection.

Compositional profiling of extracellular vesicles/lipoproteins mixtures by AFM nanomechanical imaging

This paper introduces an AFM-based method to distinguish and quantify lipoproteins and extracellular vesicles in mixed samples using nanomechanical imaging.

Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines

This study evaluates neutralizing activity against Omicron BA.1 and BA.2 variants elicited by various vaccines and finds that booster doses enhance neutralizing titers and breadth across all vaccine platforms.

SARS-CoV-2 spike conformation determines plasma neutralizing activity

This study shows that vaccines encoding a prefusion-stabilized SARS-CoV-2 spike protein induce higher neutralizing antibody titers and better variant cross-neutralization compared to other vaccines or infection.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

This study shows that Omicron variant's spike protein has enhanced ACE2 binding and reduces neutralizing activity, but some broadly neutralizing antibodies remain effective.

Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols Towards Downstream Isolation and Analysis

This study compares heat and solvent-detergent inactivation protocols for serum samples intended for extracellular vesicles analysis, finding differences in EV recovery and contamination levels.

SARS-CoV-2 epitope mapping on microarrays highlights strong immune-response to N protein region

The paper reports a workflow for identifying SARS-CoV-2 epitopes using peptide microarrays, highlighting a highly specific N protein epitope for serological testing.

Within-host competition modulates pneumococcal antibiotic resistance in the pre-vaccination era

This study uses a stochastic model to show that within-host competition explains variation in pneumococcal antibiotic resistance frequencies in the pre-vaccination era.

Evaluation of pneumococcal serotyping in nasopharyngeal carriage isolates by latex agglutination, whole genome sequencing (PneumoCaT) and DNA microarray in a high pneumococcal carriage prevalence population in Malawi

The paper evaluates three pneumococcal serotyping methods in Malawi, finding high concordance between latex agglutination, whole genome sequencing, and DNA microarray, with microarray improving detection of low-abundance vaccine serotypes.

Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+-dependent death of cancer cells

The paper shows that displacing HK2 from MAMs triggers Ca2+-dependent death of cancer cells, offering a potential anti-neoplastic strategy.

Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment

This study shows Diflunisal inhibits HMGB1-mediated immune cell recruitment by disrupting the HMGB1/CXCL12 heterocomplex without affecting TLR4-dependent responses.