Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance
J. A. Mindell, X. Leray, J. K. Hilton, K. Nwangwu, A. Becerril, V. Mikusevic, G. Fitzgerald, A. Amin, M. R. Weston
This study shows that PI(3,5)P2 inhibits ClC-7, a chloride antiporter, which is crucial for maintaining lysosomal pH.
bioRxiv · Oct 7, 2021Biophysics