BiophysicsbioRxiv
Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance
J. A. Mindell, X. Leray, J. K. Hilton…·M. R. Weston
This study shows that PI(3,5)P2 inhibits ClC-7, a chloride antiporter, which is crucial for maintaining lysosomal pH.
DOI 10.7554/elife.74136