Defining the in vivo role of mTORC1 in thyrocytes by studying the TSC2 conditional knockout mouse model
C. L. Rossetti, B. Lourenconi, F. L. M. Pecanha, A. T. Franco, V. Nose, J. Lew, E. Carneiro, E. Bernal-Mizrachi, J. P. Werneck de Castro
This study uses a TSC2 conditional knockout mouse model to show that mTORC1 activation in thyrocytes inhibits thyroid hormone biosynthesis, promotes growth, and leads to thyroid tumors.
bioRxiv · Nov 1, 2023 · PreprintPhysiology