Pharmacological tuning of microRNA in FAP-derived Extracellular Vesicles by HDAC inhibitors promotes regeneration and reduces fibrosis in dystrophic muscles.
M. Sandona, S. Consalvi, L. Tucciarone, M. De Bardi, M. Scimeca, D. F. Angelini, V. Buffa, A. D'Amico, E. S. Bertini, S. Cazzaniga, P. Bettica, M. Bouche, A. Bongiovanni, P. L. Puri, V. Saccone
The paper shows that HDAC inhibitors increase microRNA levels in FAP-derived EVs, enhancing muscle regeneration and reducing fibrosis in dystrophic models.
bioRxiv · Feb 15, 2020 · PreprintCell Biology