P. L. Puri

Extracellular vesicle-mediated promotion of myogenic differentiation is dependent on dose, collection media composition, and isolation method

This study shows that extracellular vesicles promote myogenic differentiation in C2C12 cells, but their effectiveness depends on dose, collection media, and isolation method.

Targeting SerpinE1 reverses cellular features of Hutchinson-Gilford progeria syndrome

This study identifies SerpinE1 as a therapeutic target for HGPS by showing its inhibition reverses key pathological features in patient-derived fibroblasts.

Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells

This study identifies four conserved transcription factors that oppose cell fate reprogramming by controlling chromatin accessibility and gene expression, and shows their potential as therapeutic targets for regenerative medicine.

Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence.

This study shows that HDAC inhibitors are less effective in late-stage DMD muscle FAPs due to senescence-related epigenetic changes that resist reversal.

scRNA-seq-based analysis of skeletal muscle response to denervation reveals selective activation of muscle-resident glial cells and fibroblasts

This study uses scRNA-seq to analyze skeletal muscle response to denervation, finding selective activation of muscle-resident glial cells and fibroblasts, and their role in NMJ repair and fibrosis.

Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetes patients

This study identifies CD90+ fibro-adipogenic progenitors in T2DM skeletal muscle and shows PDGF signaling drives their pathogenic behavior, which is mitigated by Metformin.

Pharmacological tuning of microRNA in FAP-derived Extracellular Vesicles by HDAC inhibitors promotes regeneration and reduces fibrosis in dystrophic muscles.

The paper shows that HDAC inhibitors increase microRNA levels in FAP-derived EVs, enhancing muscle regeneration and reducing fibrosis in dystrophic models.