Author

Vanessa Affe

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Bioengineering· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Landon J. EdgariD· 5 shared Haissi CuiiD· 3 shared Hani Choksi· 3 shared Matthew Scott MacauleyiD· 2 shared Qingyu Shi· 2 shared Aled Blundell· 1 shared Alexandra J Denhart· 1 shared Alexxandra Sosa-GuiriD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersImmunology

Landon J. EdgarORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell Surface Sialoglycan Engineering Through Exogenous mRNA

Vanessa Affe, Qingyu Shi, Olivia Mann-Delany, David Alvarez, Landon J. Edgar, Haissi Cui

This paper develops an mRNA-based platform to transiently control sialoglycan biosynthesis on human cells by delivering sialyltransferase enzymes, showing increased surface presentation of specific sialoglycans with minimal off-target effects.

bioRxiv · Sep 9, 2026 · PreprintBioengineering

Biological recognition of mirror-image glycans

Chuanhao Peng, Simatsidk Haregu, Claire Yi-Ling Yang, Shreyas Gupta, Michael Evjen, Hani Choksi, Vanessa Affe, Eric J Carpenter, Nicholas M. Twells, Mei-Ting Lin, Ayodeji Kulepa, Carolina Ortiz‐Cordero, Alexxandra Sosa-Guir, Jonathan Lefèbre, Szu Yun Wang, , Ratmir Derda

The paper evaluates how glycan-binding proteins and immune cells recognize mirror-image glycans, finding widespread binding and donor-specific recognition of L-glycans.

bioRxiv · Jul 20, 2026 · PreprintBiochemistry

An atlas of the human metabolome

Jeremy K. Chan, Nicholas S Ly, Olivia Taverniti, William D. Gwynne, Brandon Y. Lieng, Vanessa Affe, Verne T Urquhart-Cox, Sophia M. Alonzi, Mathula Muhundan, Alexandra J Denhart, Landon J. Edgar, Andrew T. Quaile, J. Rafael Montenegro-Burke

The paper presents the Human Metabolome Atlas, a comprehensive resource with metabolomic profiles of 70 human cell lines across 22 tissues, offering expanded coverage and detailed metabolic pathway insights.

bioRxiv · May 22, 2026 · PreprintSystems Biology

Sialoglycans on human T cells attenuate death programs executed through the Fas pathway

Vanessa Affe, Qianmeng Lei, Tim S. Veth, Emmajay Sutherland, Hani Choksi, Fauzia Nurul Izzati, Qingyu Shi, Haissi Cui, Nicholas McIlvain Riley, Landon J. Edgar

This study shows that sialoglycans on human T cells reduce Fas receptor-mediated apoptosis but not other TNF receptor pathways.

Journal of Biological Chemistry · Dec 12, 2025Peer-reviewedImmunology

A Unified Atlas of T cell Glycophysiology

Fauzia N. Izzati, Hani Choksi, Paolo Giuliana, Diala Abd-Rabbo, Heidi J. Elsaesser, Aled Blundell, Vanessa Affe, Vinicius Kannen, Zeinab Jame-Chenarboo, Edward N. Schmidt, Meggie Kuypers, David B. Avila, Eric S. Y. Chiu, Dzhangar Badmaev, Haissi Cui, , Landon J. Edgar

This study characterizes T cell glycosylation patterns across mouse and human tissues, revealing species-specific differences in glycan profiles and dynamics.

Cell Reports · Jul 1, 2025Peer-reviewedImmunology