Cell Surface Sialoglycan Engineering Through Exogenous mRNA
Vanessa Affe, Qingyu Shi, Olivia Mann-Delany…·Haissi Cui
This paper develops an mRNA-based platform to transiently control sialoglycan biosynthesis on human cells by delivering sialyltransferase enzymes, showing increased surface presentation of specific sialoglycans with minimal off-target effects.