Molecular BiologybioRxivPreprint
Target-matched increased fidelity SpCas9 variants can edit any target without genome-wide off-target effects
Péter István Kulcsár, András Tálas, Zoltán Ligeti…·Ervin Welker
The paper develops a set of high-fidelity SpCas9 variants that enable efficient and specific genome editing across all target sites without off-target effects.
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