A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling
Chi-Hong Wu, Vedakumar Tatavarty, Pierre MJ Beltran, Andrea Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A. Carr, Jeffrey R. Cottrell, Gina G. Turrigiano
This study identifies bidirectional phosphorylation changes in Shank3 that regulate synaptic scaling up or down in mouse and rat neurons.
eLife · Apr 26, 2022Peer-reviewedNeuroscience