Li Li

ROR2 drives right ventricular heart failure via disruption of proteostasis

This study identifies ROR2 as a driver of right ventricular failure by disrupting proteostasis, showing that modulating ROR2 can rescue structural and functional deficits in cardiomyocytes.

Autonomic neurons are intrinsically hyperexcitable in a Friedreich ataxia iPSC model

This paper establishes that FRDA autonomic neurons are hyperexcitable and exhibit mitochondrial dysfunction using iPSC-derived models.

NSD2 deficiency disrupts the epigenetic landscape of cochlear hair cells to enhance ECM expression and to perturb cochlear hair cell function

This study shows that NSD2 deficiency disrupts chromatin accessibility and gene expression in cochlear hair cells, leading to increased ECM expression and hearing impairment, which can be mitigated by ECM intervention.

Linking coronary microvascular structure and function in preclinical models of coronary microvascular disease

This study quantifies coronary microvascular structure and function in mouse models of CMVD, identifying age, sex, and metabolic factors as key contributors to disease.

Frataxin deficiency drives cardiac dysfunction and transcriptional dysregulation in Friedreich ataxia iPSC model

This study uses iPSCs from FRDA patients to model cardiac dysfunction, finding transcriptional dysregulation and phenotypes like increased cell size and mitochondrial stress.

CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer drivers

This study identifies synthetic lethal interactions between cancer drivers and tractable targets using CRISPR screens and cancer dependency data, offering new drug targets for therapy.

Senescent mast cells contribute to the progression of benign prostatic hyperplasia via SCF/c-KIT mediated endothelial-mesenchymal transition

This study identifies senescent mast cells as drivers of benign prostatic hyperplasia through SCF/c-KIT-mediated endothelial-mesenchymal transition.

The first chromosomal-level genome assembly of an allotetraploid oyster

The paper presents the first chromosomal-level genome assembly of an allotetraploid oyster, providing a genetic resource for studying genome biology and polyploid breeding.

A dual mechanism of sensitivity to PLK4 inhibition by RP-1664 in neuroblastoma

This study shows neuroblastoma cells are hypersensitive to PLK4 inhibitor RP-1664 due to dual mechanisms of centriole loss and amplification, leading to cell death.

A comprehensive analysis of the potential biological functions and prognostic values of SREBF1 for multiple cancer types including colorectal cancer

This study investigates SREBF1's role in multiple cancers, finding it correlates with prognosis and immune infiltration, and affects cell growth and migration.

PVN microglia via P2Y12 transmit hemodynamic signal to promote sympathetic excitation in hypertension

The paper identifies PVN microglia as mediators of sympathetic excitation in hypertension through P2Y12 receptor signaling triggered by vascular ATP release.

Treatment of non-alcoholic steatohepatitis with recombinant Orosomucoid 2, an acute phase protein that attenuates the Erk1/2-PPARγ-Cd36 signaling pathway

This study shows that recombinant Orm2 treatment reduces hepatic steatosis, inflammation, and fibrosis in NASH models by inhibiting the Erk1/2-PPARγ-Cd36 pathway.

A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling

This study identifies bidirectional phosphorylation changes in Shank3 that regulate synaptic scaling up or down in mouse and rat neurons.

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia

This study shows that anxiety increases pain in an osteoarthritis model and reduces opioid effectiveness by altering endogenous opioid function.

5-HAYED peptide can protect AD brain by scavenging the redundant iron ions and the catalyzed radicals

The paper demonstrates that the 5-HAYED peptide reduces brain iron and radicals, protects neurons, and improves cognition in AD mice.

Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

This study quantifies spatial proteome heterogeneity in prostate tissues using multi-region analysis and identifies biomarker variability across benign and malignant tissues.

Multiplexed confocal and super-resolution fluorescence imaging of cytoskeletal and neuronal synapse proteins

The paper introduces PRISM, a method for multiplexed imaging of synaptic proteins, enabling high-throughput quantification of co-expression and nanometer-scale organization.