Cancer BiologybioRxivPreprint
Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia
Irène Baccelli, Yves Gareau, Bernhard Lehnertz…·Guy Sauvageau
The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.
DOI 10.1101/513887