Cancer BiologybioRxiv
Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy
Magali Humbert, Kristina Seiler, Severin Mosimann…·Mario P Tschan
This study shows that reducing FASN expression enhances AML cells' response to differentiation therapy by promoting lysosomal biogenesis and TFEB activation.
DOI 10.1038/s41418-021-00768-1