S1 hydrophobic residues modulate voltage sensing phosphatase enzymatic function and voltage sensing
V. Rayaprolu, H. M. Miettinen, W. Baker, V. C. Young, M. Fisher, G. Mueller, W. O. Rankin, J. J. Kelley, W. Ratzan, L. M. Leong, J. A. Davisson, B. J. Baker, S. C. Kohout
This study shows that S1 hydrophobic residues in voltage sensing phosphatase (VSP) modulate voltage sensing and enzymatic activity by altering voltage dependence and kinetics.
bioRxiv · Dec 27, 2023Biophysics