Author

V. Rayaprolu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:virus· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:flow cytometry· 1

Frequent Co-Authors

E. O. Saphire· 3 shared D. Parekh· 2 shared K. Shaffer· 2 shared S. Hui· 2 shared W. Ratzan· 2 shared A. Baum· 1 shared A. D. Parvate· 1 shared A. Frazier· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

E. O. Saphire

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Author profile →

5 papers

Recent·Most cited

S1 hydrophobic residues modulate voltage sensing phosphatase enzymatic function and voltage sensing

V. Rayaprolu, H. M. Miettinen, W. Baker, V. C. Young, M. Fisher, G. Mueller, W. O. Rankin, J. J. Kelley, W. Ratzan, L. M. Leong, J. A. Davisson, B. J. Baker, S. C. Kohout

This study shows that S1 hydrophobic residues in voltage sensing phosphatase (VSP) modulate voltage sensing and enzymatic activity by altering voltage dependence and kinetics.

bioRxiv · Dec 27, 2023Biophysics

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Glycan shield of the ebolavirus envelope glycoprotein GP

W. Peng, V. Rayaprolu, A. D. Parvate, M. F. Pronker, S. Hui, D. Parekh, K. Shaffer, X. Yu, E. O. Saphire, J. Snijder

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

bioRxiv · Feb 7, 2022Biochemistry

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

J. M. Dan, J. Mateus, Y. Kato, K. M. Hastie, E. D. Yu, C. Faliti, A. Grifoni, S. I. Ramirez, S. Haupt, A. Frazier, C. Nakao, V. Rayaprolu, S. A. Rawlings, B. Peters, F. Krammer, , S. Crotty

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

bioRxiv · Nov 15, 2020 · PreprintImmunology

The voltage sensing phosphatase (VSP) localizes to the apical membrane of kidney tubule epithelial cells

W. Ratzan, V. Rayaprolu, S. E. Killian, R. Bradley, S. Kohout

This study identifies the apical membrane localization of VSP in kidney tubule epithelial cells and characterizes the functional differences between Xl-VSP1 and Xl-VSP2.

bioRxiv · Nov 30, 2018Cell Biology