The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence
M. M. Osman, J. K. Shanahan, F. Chu, K. Takaki, M. Pinckert, A. J. Pagan, R. Brosch, W. Conrad, L. Ramakrishnan
This paper identifies conserved residues in the C-terminal tail of ESAT-6 required for phagosomal damage and virulence, while showing that secretion levels remain near-normal in these mutants.
bioRxiv · Jan 14, 2022Microbiology