Author

R. Brosch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 8 Organism:human· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2

Frequent Co-Authors

F. Sayes· 3 shared W. Frigui· 3 shared A. Giraud-Gatineau· 2 shared A. Maure· 2 shared A. Pawlik· 2 shared L. Majlessi· 2 shared L. S. Ates· 2 shared L. Tailleux· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

F. Sayes

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Author profile →

10 papers

Recent·Most cited

A marine sponge-associated mycobacterium closely related to Mycobacterium tuberculosis

S. J. Pidot, S. Klatt, L. S. Ates, W. Frigui, F. Sayes, L. Majlessi, H. Izumi, I. R. Monk, J. L. Porter, V. Bennett-Wood, T. Seemann, A. Otter, G. Taiaroa, G. M. Cook, N. West, , T. P. Stinear

This paper describes the discovery of a marine sponge-associated mycobacterium closely related to M. tuberculosis, which shares virulence factors but lacks virulence in mice.

bioRxiv · Jan 23, 2024 · PreprintMicrobiology

An oxadiazole-based compound potentiates anti- tuberculosis treatment by increasing host resistance via zinc poisoning

A. Maure, E. Lawaree, F. Fiorentino, A. Pawlik, S. Gona, A. Giraud-Gatineau, M. J. G. Eldridge, A. Danckaert, D. Hardy, W. Frigui, C. Keck, N. Aulner, A. Mai, M. Hamon, L. B. Barreiro, , L. Tailleux

The paper identifies oxadiazole-based compounds that enhance anti-tuberculosis treatment by increasing host resistance through zinc poisoning of Mycobacterium tuberculosis.

bioRxiv · Jul 21, 2023 · PreprintMicrobiology

A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome

P. Chitale, A. D. Lemenze, E. C. Fogarty, A. Shah, C. A. Grady, A. R. Odom-Mabey, W. E. Johnson, J. H. Yang, A. M. Eren, R. Brosch, P. Kumar, D. Alland

The paper updates the M. tuberculosis H37Rv reference genome using Bact-Builder, revealing 6.4 kb of new sequence and ten new regions in widely used strains.

bioRxiv · Jul 15, 2022Microbiology

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence

M. M. Osman, J. K. Shanahan, F. Chu, K. Takaki, M. Pinckert, A. J. Pagan, R. Brosch, W. Conrad, L. Ramakrishnan

This paper identifies conserved residues in the C-terminal tail of ESAT-6 required for phagosomal damage and virulence, while showing that secretion levels remain near-normal in these mutants.

bioRxiv · Jan 14, 2022Microbiology

Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response.

A. Lima, A. Leyva, B. Rivera, M. M. Portela, M. Gil, A. Cascioferro, M. N. Lisa, A. M. Wehenkel, M. Bellinzoni, P. Carvalho, C. Batthyany, M. N. Alvarez, R. Brosch, P. M. Alzari, R. Duran

This study uses proteomics to show that PknG knockout in M. tuberculosis alters the proteome, affecting cell envelope biosynthesis and hypoxia response.

bioRxiv · Mar 16, 2021Biochemistry

IL-1R1 dependent signals improve clearance of cytosolic virulent mycobacteria in vivo

S. van der Niet, M. van Zon, K. de Punder, A. Grootemaat, S. Rutten, S. Moorlag, D. Houben, A. van der Sar, W. Bitter, R. Brosch, R. Hernandez, M. T. Pena, P. J. Peters, E. E. Reits, K. D. Mayer-Barber, N. van der Wel

The paper shows that IL-1R1-dependent signals enhance clearance of cytosolic mycobacteria in vivo, particularly when host immunity is compromised.

bioRxiv · Sep 27, 2020Cell Biology

Phthiocerol dimycocerosates from Mycobacterium tuberculosis increase the membrane activity of bacterial effectors and host receptors

J. Augenstreich, E. Haanappel, F. Sayes, R. Simeone, V. Guillet, S. Mazeres, C. Chalut, L. Mourey, R. Brosch, C. Guilhot, C. Astarie-Dequeker

This study shows that phthiocerol dimycocerosates (DIM) from Mycobacterium tuberculosis increase membrane activity of both bacterial effectors and host receptors, aiding immune evasion.

bioRxiv · May 13, 2020Microbiology

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

A. Giraud-Gatineau, J. M. Coya, A. Maure, A. Biton, M. Thomson, E. M. Bernard, M. G. Gutierrez, G. Larrouy-Maumus, R. Brosch, B. Gicquel, L. Tailleux

The paper shows that bedaquiline reprograms macrophages to enhance bactericidal activity against bacteria through metabolic and lysosomal pathways.

bioRxiv · Sep 6, 2019Immunology

Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages

V. Dubois, A. Pawlik, A. Bories, V. Le Moigne, O. Sismeiro, R. Legendre, H. Varet, P. Rodriguez, J.-L. Gaillard, J.-Y. Copee, R. Brosch, J.-L. Herrmann, F. Girard-misguich

This study identifies genes in Mycobacterium abscessus that enhance survival in macrophages by analyzing transcriptomes in amoebae and macrophages.

bioRxiv · Jan 23, 2019Microbiology

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

L. S. Ates, F. Sayes, W. Frigui, R. Ummels, M. P. M. Damen, D. Bottai, M. A. Behr, W. Bitter, L. Majlessi, R. Brosch

This study shows that BCG vaccine strains lack PE_PGRS/PPE-MPTR export due to RD5 inactivation, reducing antigenic repertoire but not vaccine efficacy.

bioRxiv · Feb 14, 2018Microbiology