MicrobiologybioRxiv
The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence
M. M. Osman, J. K. Shanahan, F. Chu…·L. Ramakrishnan
This paper identifies conserved residues in the C-terminal tail of ESAT-6 required for phagosomal damage and virulence, while showing that secretion levels remain near-normal in these mutants.