Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells
T. Buenaventura, W. E. Laughlin, S. Bitsi, T. Burgoyne, Z. Lyu, A. I. Oqua, H. Norman, E. R. McGlone, A. S. Klymchenko, I. R. Correa, A. Walker, A. Inoue, A. Hanyaloglou, G. A. Rutter, S. R. Bloom, , A. Tomas
This study shows that agonist binding affinity affects GLP-1R palmitoylation, nanodomain clustering, and signaling in pancreatic beta cells, influencing insulin secretion.
bioRxiv · Dec 10, 2018Cell Biology