A. Walker

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses

This paper develops a stabilized MERS-CoV spike ferritin nanoparticle vaccine that elicits strong neutralizing antibodies in mice and non-human primates, providing protection against MERS-CoV infection.

An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries

The paper introduces MAGMA-seq, a technology for quantitative analysis of antibody sequence-function relationships, demonstrating its application in mapping antibody development pathways and identifying binding determinants.

Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer's disease

This study shows that Robo4 deletion increases neuroinflammation and impairs motor coordination in Alzheimer's disease mice, with effects dependent on AD mutations and brain region.

Piscichuviral encephalitis in marine and freshwater chelonians: first evidence of jingchuviral disease

This study identifies three novel chuviruses as the cause of lymphocytic meningoencephalomyelitis in three aquatic turtles, providing the first in situ evidence of chuviral pathogenicity in animals.

Long-term fertilization modifies the composition of slow-growing oligotrophs more than fast-growing copiotrophs in a nutrient poor coastal plain wetland

This study shows long-term fertilization reduces oligotrophic bacteria in wetland soils, potentially decreasing carbon storage capacity.

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV-2 nsp3 Macrodomain

This study designs and synthesizes inhibitors targeting the SARS-CoV-2 nsp3 macrodomain, identifying compound 15c as a low-micromolar inhibitor with structural and thermal evidence of binding.

Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection

This study investigates susceptibility of peridomestic mammals to SARS-CoV-2 infection, finding some species can be infected and shed the virus while others are not susceptible.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

A Tunable, Simplified Model for Biological Latch Mediated Spring Actuated Systems

The paper develops a tunable model of LaMSA systems and compares their performance to directly actuated systems, finding that including dynamic muscle properties enhances LaMSA performance.

SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects

This study shows SARS-CoV-2 infects cortical neurons in 3D human brain organoids, causing neurodegeneration-like effects such as Tau mislocalization and neuronal death.

Longitudinal profiles of dietary and microbial metabolites in formula- and breastfed infants

The paper examines fecal metabolites in formula- and breastfed infants to compare dietary and microbial influences on the gut metabolome over the first year of life.

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

This paper shows enisamium and its metabolite VR17-04 inhibit RNA polymerases of influenza A and SARS-CoV-2, with VR17-04 matching remdesivir's efficacy against SARS-CoV-2.

Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

This study shows that agonist binding affinity affects GLP-1R palmitoylation, nanodomain clustering, and signaling in pancreatic beta cells, influencing insulin secretion.

Epidemiology of paediatric gastrointestinal colonisation by extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in north-west Cambodia

The paper investigates ESC-R-EC and ESC-R-KP colonization in Cambodian children, identifies risk factors, and characterizes resistance gene diversity and genetic contexts.