S. Bitsi

An examination of the divergent spatiotemporal signaling of GLP-1R versus GIPR in pancreatic beta cells

This study compares the trafficking and signaling of GLP-1R and GIPR in pancreatic beta cells, revealing differences in internalization, recycling, and subcellular activity.

Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice

This study examines GLP-1R responses in beta cell-specific β-arrestin 2 knockout mice, finding acute deficits and prolonged effects with certain agonists.

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

This study shows that partial agonism of GLP-1R/GCGR co-agonists improves anti-hyperglycaemic efficacy by reducing β-arrestin-2 recruitment, leading to prolonged glucose-lowering effects and comparable weight loss to liraglutide.

Testosterone enhances GLP-1 efficacy at the plasma membrane and endosomes to augment insulin secretion in male pancreatic β cells

This paper shows testosterone enhances GLP-1's ability to increase insulin secretion in male β cells by boosting cAMP production at the plasma membrane and endosomes.

Differences in signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

This study compares the signalling, trafficking, and glucoregulatory effects of exendin-4 and lixisenatide, finding differences in cAMP signalling potency and receptor recycling that impact glucose control.

Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

This study shows that agonist binding affinity affects GLP-1R palmitoylation, nanodomain clustering, and signaling in pancreatic beta cells, influencing insulin secretion.