Author

W. Guba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Le Gouill· 2 shared M. Bouvier· 2 shared T. Miljus· 2 shared U. Grether· 2 shared A. C. Rufer· 1 shared A. Kimbara· 1 shared A. Morales-Pastor· 1 shared A. Osterwald· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

C. Le Gouill

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Author profile →

2 papers

Recent·Most cited

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

A. Morales-Pastor, T. Miljus, T. M. Stepniewski, V. Ledesma, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

bioRxiv · Feb 27, 2024 · PreprintCell Biology

Diverse chemotypes drive biased signaling by cannabinoid receptors

T. Miljus, F. M. Heydenreich, T. Gazzi, A. Kimbara, M. Rogers-Evans, M. Nettekoven, E. Zirwes, A. Osterwald, A. C. Rufer, C. Ullmer, W. Guba, C. Le Gouill, J. Fingerle, M. Nazare, U. Grether, , D. B. Veprintsev

This study identifies chemotype-specific biased signaling in cannabinoid receptors by analyzing ligand-induced signaling cascades.

bioRxiv · Nov 9, 2020 · PreprintPharmacology & Toxicology