Competition NMR for Detection of Hit/Lead Inhibitors of Protein-Protein Interactions
B. Musielak, W. Janczyk, J. Plewka, I. Rodriguez, D. Sala, K. Magiera-Mularz, T. Holak
The paper introduces a sensitive NMR competition assay to detect weak inhibitors of protein-protein interactions, demonstrating its use with Mdm2/X-p53 and PD-1/PD-L1 complexes.
bioRxiv · Jun 12, 2020Biophysics