Author

D. Sala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 4 Approach:deep learning· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

J. Meiler· 3 shared B. Musielak· 2 shared D. del Alamo· 2 shared J. Plewka· 2 shared K. Magiera-Mularz· 2 shared A. Giachetti· 1 shared A. Rosato· 1 shared C. Luchinat· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiophysics

J. Meiler

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Author profile →

6 papers

Recent·Most cited

Biasing AlphaFold2 to predict GPCRs and Kinases with user-defined functional or structural properties

D. Sala, J. Meiler

The paper extends AlphaFold2 to predict GPCRs and Kinases by incorporating user-defined functional or structural features, achieving accurate models with biased conformational states.

bioRxiv · Dec 11, 2022Biophysics

Modeling of protein conformational changes with Rosetta guided by limited experimental data

D. Sala, D. del Alamo, H. S. Mchaourab, J. Meiler

This paper introduces ConfChangeMover (CCM), a Rosetta tool for modeling protein conformational changes using sparse experimental data, and shows it outperforms existing methods.

bioRxiv · Feb 14, 2022Biophysics

Sampling the conformational landscapes of transporters and receptors with AlphaFold2

D. del Alamo, D. Sala, H. Mchaourab, J. Meiler

This study uses AlphaFold2 to generate multiple conformations of transporters and GPCRs, showing that reducing MSA depth improves conformational sampling accuracy.

bioRxiv · Nov 22, 2021Biophysics

Competition NMR for Detection of Hit/Lead Inhibitors of Protein-Protein Interactions

B. Musielak, W. Janczyk, J. Plewka, I. Rodriguez, D. Sala, K. Magiera-Mularz, T. Holak

The paper introduces a sensitive NMR competition assay to detect weak inhibitors of protein-protein interactions, demonstrating its use with Mdm2/X-p53 and PD-1/PD-L1 complexes.

bioRxiv · Jun 12, 2020Biophysics

A protocol to automatically calculate homo-oligomeric protein structures through the integration of evolutionary constraints and ambiguous contacts derived from solid- or solution-state NMR

D. Sala, L. Cerofolini, M. Fragai, A. Giachetti, C. Luchinat, A. Rosato

The paper presents a protocol to calculate homo-oligomeric protein structures by integrating evolutionary constraints with ambiguous NMR contacts, validated on L-asparaginase II and Sod1.

bioRxiv · Jul 30, 2019Biophysics

CA-170 a potent small-molecule PD-L1 inhibitor or not?

B. Musielak, J. Kocik, L. Skalniak, K. Magiera-Mularz, D. Sala, M. Czub, T. A. Holak, J. Plewka

The paper investigates whether CA-170, a small-molecule PD-L1 inhibitor, binds to hPD-L1 using biophysical assays and finds no direct binding.

bioRxiv · Jun 6, 2019Cancer Biology