Author

W. L. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Z. Cheng· 1 shared C. Belica· 1 shared C. Wick· 1 shared D. Sauter· 1 shared H. Nasser· 1 shared J. T. Becker· 1 shared M. A. Carpenter· 1 shared R. Harris· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

A. Z. Cheng

Mutual co-authors in cluster

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2 papers

Recent·Most cited

APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1

T. Ikeda, R. Shimizu, H. Nasser, M. A. Carpenter, A. Z. Cheng, W. L. Brown, D. Sauter, R. S. Harris

This study shows that HIV-1 Vif primarily degrades A3 enzymes to enable viral replication in THP-1 cells, as disrupting A3 proteins restores infectivity of Vif-deficient viruses.

bioRxiv · Mar 28, 2023 · PreprintMicrobiology

Gain-of-function assay for SARS-CoV-2 Mpro inhibition in living cells

S. A. Moghadasi, J. T. Becker, C. Belica, C. Wick, W. L. Brown, R. Harris

The paper develops a gain-of-function assay to measure SARS-CoV-2 Mpro inhibition in living cells, using eGFP fluorescence to quantify inhibitor potency and enable high-throughput drug testing.

bioRxiv · Nov 9, 2020 · PreprintMicrobiology