D. Sauter

Tetherin restricts SARS-CoV-2 replication despite antagonistic effects of Spike and ORF7a

This study shows that SARS-CoV-2 S and ORF7a antagonize Tetherin, but Tetherin still restricts SARS-CoV-2 replication.

APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1

This study shows that HIV-1 Vif primarily degrades A3 enzymes to enable viral replication in THP-1 cells, as disrupting A3 proteins restores infectivity of Vif-deficient viruses.

ORF3c is expressed in SARS-CoV-2 infected cells and suppresses immune activation by inhibiting innate sensing

This study identifies ORF3c as an immune evasion factor of SARS-CoV-2 that suppresses innate sensing by inhibiting RIG-I and MDA5 signaling.

Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV 1/SIVcpz lentiviral lineage

This paper shows that Nef proteins from HIV and SIV use different structural strategies, called R-clamps, to bind SH3 domains, with variations in amino acids at positions 83 and 120.

Acute myeloid leukemia cells are targeted by the naturally occurring CXCR4 antagonist EPI-X4

The paper was withdrawn due to unresolved data contribution and authorship issues, and the authors request it not be cited as a reference.

CXCR4 signaling is counteracted by the naturally occurring CXCR4 antagonist EPI-X 4 in Waldenstrom Macroglobulinemia

This study shows that the natural CXCR4 antagonist EPI-X4 inhibits Waldenstrom Macroglobulinemia cell growth and migration, with optimized derivatives showing enhanced efficacy.

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

This study shows that IFITM proteins are required for SARS-CoV-2 infection and can be targeted to inhibit viral entry and replication.

The Zinc Finger Antiviral Protein restricts SARS-CoV-2

This paper identifies ZAP as an IFN-induced antiviral effector that restricts SARS-CoV-2 by targeting CpG dinucleotides, though SARS-CoV-2 may be adapted to low CpG environments.