MicrobiologybioRxivPreprint
APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1
T. Ikeda, R. Shimizu, H. Nasser…·R. S. Harris
This study shows that HIV-1 Vif primarily degrades A3 enzymes to enable viral replication in THP-1 cells, as disrupting A3 proteins restores infectivity of Vif-deficient viruses.
DOI 10.1101/2023.03.28.534666