R. S. Harris

This study develops a first-in-class Aurora-A/N-Myc degrader, HLB-0532259, which effectively reduces N-Myc levels and shows tumor reduction in neuroblastoma models.

This study quantifies the mutagenic activities of APOBEC3A and APOBEC3B in a human cell line and compares their mutation signatures to breast cancer genomes, showing both enzymes contribute to the mutation landscape.

This study identifies and characterizes SARS-CoV-2 Mpro mutations conferring resistance to nirmatrelvir using a VSV-based system and biochemical assays.

This study shows that HIV-1 Vif primarily degrades A3 enzymes to enable viral replication in THP-1 cells, as disrupting A3 proteins restores infectivity of Vif-deficient viruses.

This paper identifies a structural basis for inhibiting APOBEC3A, a mutagenic enzyme in cancer, using a hairpin DNA inhibitor that blocks its activity in human cells.

This paper shows that human cytomegalovirus (HCMV) relocalizes APOBEC3B from the nucleus to the cytoplasm through an RNR-independent mechanism, unlike related herpesviruses.

This study shows BKPyV infection increases APOBEC3-mediated genomic damage in urothelial cells, contributing to bladder cancer risk in immunocompromised individuals.

This study analyzes Y chromosome evolution in great apes, finding accelerated substitution and gene death rates in Pan, and reveals roles for palindromes in gene conversion and regulatory site preservation.

This study shows that herpesviruses use viral ribonucleotide reductase subunits to relocalize APOBEC3B and APOBEC3A, suggesting a conserved mechanism to evade innate immunity.

The paper uses short- and long-read sequencing to study satellite repeat turnover in great apes, finding rapid repeat evolution and species-specific patterns.

This study reports structures of APOBEC3B with loop 7 from APOBEC3G, revealing inactive conformations stabilized by small molecules, providing insights for inhibitor design.