MicrobiologybioRxiv
Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead
N. G. R. D. Elshan, K. C. Wolff, L. Riva…·A. K. Chatterjee
This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.
DOI 10.1021/acs.jmedchem.3c01938