Author

W. McConaughy

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

B. Zhao· 1 shared J. Jackson· 1 shared J. R. Engen· 1 shared M. Pirruccello-Straub· 1 shared R. E. Iacob· 1 shared T. A. Springer· 1 shared V. Q. Le· 1 shared Y. Su· 1 shared

Activity by Year

2017-2017 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

B. Zhao

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1 paper

Recent·Most cited

Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation

V. Q. Le, R. E. Iacob, Y. Tian, W. McConaughy, J. Jackson, Y. Su, B. Zhao, J. R. Engen, M. Pirruccello-Straub, T. A. Springer

This study shows Tolloid cleavage activates latent GDF8 by destabilizing prodomain-growth factor interfaces and priming the growth factor for release.

bioRxiv · Aug 3, 2017Biochemistry