T. A. Springer

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

Conformational change of the Plasmodium TRAP I domain is essential for sporozoite migration and transmission of malaria

This study shows that conformational changes in the Plasmodium TRAP I-domain are essential for sporozoite gliding, salivary gland entry, and malaria transmission.

Subtype-specific single β1 integrin mechanics for activation, mechanotransduction and cytoskeleton remodeling

The paper investigates subtype-specific mechanics of β1 integrins in cell spreading, showing different tension thresholds and cytoskeletal remodeling for integrin α4β1 versus RGD-binding integrins.

Von Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker

This study investigates how O-glycosylated N- and C-linkers regulate the affinity and stability of the A1 domain of von Willebrand factor for GPIbα, revealing differential effects on binding and structural dynamics.

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

The paper reports monoclonal antibodies against Plasmodium berghei HAP2 and their crystal structures, showing how they block malaria transmission.

Low affinity integrin states have faster binding kinetics than the high affinity state

The paper measures ligand-binding kinetics of integrin states and finds low-affinity states bind faster than the high-affinity state.

Protection of the prodomain 1-helix correlates with latency in the transforming growth factor- family

The paper investigates the structural basis of latency in TGF-beta family members by comparing conformational states and hydrogen-deuterium exchange patterns across multiple family members.

Design and assessment of TRAP-CSP fusion antigens as effective malaria vaccines

This study designs and evaluates TRAP-CSP fusion antigens as malaria vaccines, finding that those containing the CSP repeat region provide complete sterile protection in mice.

Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation

This study shows Tolloid cleavage activates latent GDF8 by destabilizing prodomain-growth factor interfaces and priming the growth factor for release.

Prodomain-Growth Factor Swapping in the Structure of pro-TGF-β1

The paper determines the structure of pro-TGF-β1 with a cleavage site mutation, revealing prodomain-GF domain swapping in the dimeric structure and its implications for TGF-β biosynthesis.

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

The paper shows that integrin orientation is dictated by actin flow direction and cytoskeletal forces during leukocyte migration.