Y. Su

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

The paper constructs a transcriptomic atlas of immune cells across human lifespan and develops a biological age prediction model using scRNA-seq and bulk RNA-seq data.

Nuclear blebs are associated with destabilized chromatin packing domains

The paper investigates how nuclear blebs alter chromatin packing domains, finding fragmentation of nanoscopic heterochromatin domains within blebs.

Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity

This study shows that bacterial differentiation through altruistic feeding and cell-cell signaling increases phenotypic heterogeneity, enhancing population resilience to environmental changes.

Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM)

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

This study shows that Neuropilin-1 (NRP1) on perivascular cells modulates VEGFA/VEGFR2 signaling in endothelial cells, affecting vascular permeability in a tissue-specific manner.

Mitochondrial ncRNA LDL-805 declines in alveolar epithelial type 2 cells of chronic obstructive pulmonary disease patients.

This study identifies a human homologue of a mitochondrial noncoding RNA that translocates to the nucleus and enhances mitochondrial bioenergetics in response to cigarette smoke, but its levels decline in chronic obstructive pulmonary disease.

Phase diversity-based wavefront sensing for fluorescence microscopy

This paper introduces a phase diversity-based wavefront sensing method for fluorescence microscopy to correct optical aberrations efficiently and accurately.

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy

This paper introduces a deep learning method to correct optical aberrations in fluorescence microscopy, improving image quality and enabling better downstream analysis.

The SARS-CoV-2 nucleoprotein associates with anionic lipid membranes

This study identifies the SARS-CoV-2 nucleoprotein's ability to bind anionic lipids, supporting a model for its role in viral membrane association during assembly.

Cell division machinery drives cell-specific gene activation during bacterial differentiation

The paper shows that the cell division machinery in Bacillus subtilis drives asymmetric localization of DivIVA and SpoIIE, leading to cell-specific activation of σF during sporulation.

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

Augmented Super-Resolution Radial Fluctuations (aSRRF) Pushing the Limits of Structured Illumination Microscopy

The paper introduces aSRRF, a method that enhances SIM resolution to ~50 nm isotropically using image augmentation without changing the optical setup or sample acquisition.

Transcription factor ScWRKY4 in sugarcane negatively regulates the resistance to pathogen infection through the JA signaling pathway

This study identifies ScWRKY4 as a negative regulator of sugarcane resistance to pathogens via the JA signaling pathway by suppressing JAZ gene expression.

Pannexin 1 modulates angiogenic activities of human endothelial colony-forming cells through IGF-1 mechanism and is a marker of senescence

This study shows that reducing Panx1 in senescent endothelial colony-forming cells increases IGF-1 production, improving angiogenic activity and limb perfusion in mice.

The Haemophilus influenzae in vivo gene expression reveals major clues about bacterial central metabolism, acquisition of trace elements, and other essential pathways during infection of the human lung

This study compares the in vivo and in vitro transcriptomes of Haemophilus influenzae during pneumonia, identifying key differences in gene expression related to metabolism, iron acquisition, and stress response.

ALOX15, a new potential functional target of lung adenocarcinoma

This study investigates the role of ALOX15 in lung adenocarcinoma, finding that its downregulation correlates with tumor differentiation, proliferation, and metastasis, and that overexpression inhibits cancer cell growth.

Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

This paper identifies a structural basis for inhibiting APOBEC3A, a mutagenic enzyme in cancer, using a hairpin DNA inhibitor that blocks its activity in human cells.

Brainstem Dbh+ Neurons Control Chronic Allergen-Induced Airway Hyperreactivity

This study identifies Dbh+ neurons in the brainstem as critical for chronic allergen-induced airway hyperreactivity through molecular, anatomical, and functional analyses.

Three-dimensional structured illumination microscopy with enhanced axial resolution

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

This study analyzes NSP10 variants in SARS-CoV-2 using genomic data and biophysical methods, finding limited functional changes and strong conservation in its interactions with NSP14 and NSP16.

New high-resolution maps show that rubber causes significant deforestation

The paper uses satellite data to show rubber expansion caused more deforestation in Southeast Asia than previously estimated, highlighting the need for updated policies.

Label-free cleared tissue microscopy and machine learning for 3D histopathology of biomaterial implants

This study uses cleared tissue microscopy and machine learning to analyze 3D histopathology of biomaterial implants and their interaction with tissue microenvironments.

CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

Treatment of prostate cancer with CD46 targeted 225Ac alpha particle radioimmunotherapy

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

A non-ligand surrogate agonist antibody that enhances canonical Wnt signaling and bone regeneration

This paper describes an antibody that enhances Wnt signaling and promotes bone regeneration without requiring exogenous Wnt ligands, showing efficacy in a mouse model of bone loss.

Toxicity of microplastics and plastic additive co-exposure in liver Disse organoids from healthy donors and patient-derived induced pluripotent stem cells

This study uses hiPSC-derived organoids to show that co-exposure to microplastics and TBBPA increases toxicity in patient-derived organoids compared to healthy ones.

Swim bladder resonance enhances hearing in crucian carp (Carassius auratus)

The paper demonstrates that swim bladder resonance enhances hearing in crucian carp through auditory evoked potentials, Micro-CT, and numerical simulations.

Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcoma

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.