J. R. Engen

This study presents the first structural analysis of full-length BTK, revealing conformational heterogeneity in the PHTH-PRR region and providing insights into BTK activation mechanisms.

This study investigates how mutations in CDR1 and CDR3 regions of human immunoglobulin κ1 light chains influence amyloid formation through structural and dynamic analyses.

This paper improves hydrogen deuterium exchange mass spectrometry by increasing flow rates under quench conditions, enhancing separation efficiency and deuterium recovery.

This study uses HDX-MS to map the cotranslational folding pathway of E. coli dihydrofolate reductase, revealing structured intermediates and chaperone interactions on the ribosome.

This study investigates how O-glycosylated N- and C-linkers regulate the affinity and stability of the A1 domain of von Willebrand factor for GPIbα, revealing differential effects on binding and structural dynamics.

This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.

This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.

The paper investigates the structural basis of latency in TGF-beta family members by comparing conformational states and hydrogen-deuterium exchange patterns across multiple family members.

This study determines the crystal structure of the WRN helicase core and identifies structural features that may aid in designing inhibitors against WRN helicase.

The paper investigates how mitochondrial ClpX partially unfolds ALAS to activate it by gating cofactor access.

This study characterizes the structure, function, and dynamics of the gamete fusogen HAP2, revealing dynamic regions and structural features critical for fusion.

This study shows Tolloid cleavage activates latent GDF8 by destabilizing prodomain-growth factor interfaces and priming the growth factor for release.